Anti- human TIMP1 Antibody, Mouse Monoclonal
Cov ntsiab lus ntawm cov khoom
Cov ntaub ntawv dav dav
TIMP metallopeptidase inhibitor 1, tseem hu ua TIMP-1 / TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating kev ua, TPA-S1TPA-induced proteinTissue inhibitor ntawm metalloproteinases 1, yog ib qho ntuj tsim inhibitors ntawm matrix metalloproteinases (MMPeptsidases), koom nrog hauv degradation ntawm extracellular matrix.TIMP-1/TIMP1 muaj nyob rau hauv cov ntaub so ntswg fetal thiab cov neeg laus.Cov qib siab tshaj plaws muaj nyob rau hauv pob txha, ntsws, zes qe menyuam thiab uterus.Complexes nrog metalloproteinases thiab irreversibly inactivates lawv los ntawm khi rau lawv catalytic zinc cofactor.TIMP-1 / TIMP1 mediates erythropoiesis hauv vitro;tab sis, tsis zoo li IL-3, nws yog hom tshwj xeeb, txhawb kev loj hlob thiab kev sib txawv ntawm tib neeg thiab murine erythroid progenitors.Ntxiv rau nws lub luag haujlwm inhibitory tiv thaiv feem ntau ntawm MMPs paub, cov protein muaj peev xwm txhawb kev loj hlob ntawm tes hauv ntau hom cell, thiab kuj tseem tuaj yeem muaj kev tiv thaiv apoptotic.Transcription ntawm no protein encoding noob yog heev inducible nyob rau hauv teb rau ntau cytokines thiab cov tshuaj hormones.Tsis tas li ntawd, cov lus qhia los ntawm qee qhov tab sis tsis yog tag nrho cov tsis muaj zog X chromosomes qhia tias cov noob tsis ua haujlwm yog polymorphic hauv tib neeg cov poj niam.Cov noob encoding no nyob rau hauv intron 6 ntawm synapsin I gene thiab tau sau nyob rau hauv qhov sib txawv.Complexes nrog metalloproteinases thiab irreversibly inactivates lawv los ntawm khi rau lawv catalytic zinc cofactor.TIMP-1 / TIMP1 paub ua haujlwm ntawm MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 thiab MMP-16.
Cov khoom
| Pair pom zoo | CLIA (Capture-Detection): 1D5-5 ~ 3G11-6 1D12-2 ~ 1G3-7 |
| Purity | > 95% raws li kev txiav txim los ntawm SDS-PAGE. |
| Buffer Formulation | PBS, pH 7.4. |
| Cia | Khaws nws nyob rau hauv cov xwm txheej tsis muaj menyuam ntawm -20 ℃ to -80 ℃ thaum tau txais. Pom zoo kom aliquot cov protein rau hauv me me kom pom kev cia. |
Kev sib piv
Cov ntaub ntawv xaj
| Khoom npe | Cat.Tsis muaj | Clone ID |
| TIM 1 | AB 0034-1 | 1D 5-5 |
| AB 0034-2 | 1D12-2 | |
| AB 0034-3 | 1 G3-7 | |
| AB 0034-4 | 3 G11-6 |
Lus Cim: Bioantibody tuaj yeem kho qhov ntau npaum li koj xav tau.
Citations
1.Barylski M, Kowalczyk E, Szadkowska I, et al.[Cov ntaub so ntswg inhibitor ntawm metalloproteinases [J].Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30(178:246-8.
2.Hayakawa T, Yamashita K, Tanzawa K, et al.Kev loj hlob-txhawb kev ua haujlwm ntawm cov ntaub so ntswg inhibitor ntawm metalloproteinases-1 (TIMP-1) rau ntau lub hlwb Ib qhov ua tau tshiab loj hlob hauv cov ntshav [J].FEBS Letters, 1992, 298.
3. Haider DG, Karin S, Gerhard P, et al.Serum retinol-binding protein 4 yog txo tom qab poob phaus hauv morbidly rog rog.[J].Phau ntawv Journal of Clinical Endocrinology & Metabolism (3): 1168-71.
