Anti-tib neeg MMP-3 Antibody, Mouse Monoclonal
Cov ntsiab lus ntawm cov khoom
Cov ntaub ntawv dav dav
Matrix metallopeptidase 3 (lub npe hu ua MMP3) kuj hu ua stromelysin 1 thiab progelatinase.MMP3 yog ib tug tswv cuab ntawm tsev neeg matrix metalloproteinase (MMP) uas nws cov tswv cuab tau koom nrog hauv kev tawg ntawm extracellular matrix nyob rau hauv ib txwm physiological txheej txheem, xws li embryonic txoj kev loj hlob, kev loj hlob, kev tsim kho, cov ntaub so ntswg, thiab cov txheej txheem kab mob xws li mob caj dab thiab metastasis.Raws li qhov zais cia zinc-dependent endopeptidase, MMP3 siv nws lub luag haujlwm feem ntau hauv cov matrix extracellular.Cov protein no yog qhib los ntawm ob qhov tseem ceeb endogenous inhibitors: alpha2-macroglobulin thiab cov ntaub so ntswg inhibitors ntawm metalloproteases (TIMPs).MMP3 ua lub luag haujlwm tseem ceeb hauv kev degrading collagen hom II, III, IV, IX, thiab X, proteoglycans, fibronectin, laminin, thiab elastin.Tsis tas li, MMP3 tuaj yeem ua haujlwm rau lwm yam MMPs xws li MMP1, MMP7, thiab MMP9, ua rau MMP3 tseem ceeb hauv kev kho cov ntaub so ntswg.Dysregulation ntawm MMPs tau cuam tshuam rau ntau yam kab mob xws li mob caj dab, mob rwj, mob encephalomyelitis, thiab mob qog noj ntshav.Synthetic los yog natural inhibitors ntawm MMPs ua rau inhibition ntawm metastasis, thaum nce-txoj cai ntawm MMPs coj mus rau kev txhim kho mob qog noj ntshav ntawm tes.
Cov khoom
| Pair pom zoo | CLIA (Capture-Detection): 11G11-6 ~ 8A3-9 11G11-6 ~ 5B9-4 |
| Purity | > 95%, txiav txim los ntawm SDS-PAGE |
| Buffer Formulation | PBS, pH 7.4. |
| Cia | Khaws nws nyob rau hauv cov xwm txheej tsis muaj menyuam ntawm -20 ℃ to -80 ℃ thaum tau txais. Pom zoo kom aliquot cov protein rau hauv me me kom pom kev cia. |
Kev sib piv
Cov ntaub ntawv xaj
| Khoom npe | Cat.Tsis muaj | Clone ID |
| MMP-3 | AB 0025-1 | 11 G11-6 |
| AB 0025-2 | 8 A3-9 | |
| AB 0025-3 | 5B 9-4 |
Lus Cim: Bioantibody tuaj yeem kho qhov ntau npaum li koj xav tau.
Citations
1.Yamanaka H, Matsuda Y, Tanaka M, et al.Serum matrix metalloproteinase 3 raws li kev kwv yees ntawm qib ntawm kev sib koom ua ke puas tsuaj thaum lub sijhawm rau lub hlis tom qab ntsuas, hauv cov neeg mob uas muaj mob caj dab thaum ntxov [J].Arthrits & Rheumatism, 2000, 43(4): 852–858.
2. Hattori Y, Kida D, Kaneko A.Ib txwm cov ntshav ntshav matrix metalloproteinase-3 qib tuaj yeem siv los kwv yees kev kho mob thiab kev ua haujlwm ntawm lub cev hauv cov neeg mob rheumatoid mob caj dab [J].Clinical Rheumatology, 2018.
