Helicobacter pylori (HP) yog cov kab mob uas nyob hauv lub plab thiab ua rau lub plab mucosa thiab intercellular qhov chaw, ua rau mob.HP tus kab mob yog ib qho ntawm cov kab mob ntau tshaj plaws, kis ntau lab tus tib neeg thoob ntiaj teb.Lawv yog cov ua rau ulcers thiab gastritis (mob plab hauv ob sab phlu).

Kev kis tus kab mob siab hauv cov menyuam yaus thiab tsev neeg sib sau ua ke yog cov yam ntxwv tseem ceeb ntawm HP tus kab mob, thiab kev sib kis hauv tsev neeg yuav yog txoj hauv kev tseem ceeb ntawm HP tus kab mob yog qhov ua rau muaj kev cuam tshuam loj hauv kev mob plab hnyuv, peptic ulcer, gastric mucosa-associated lymphoid nqaij (MALT) lymphoma, thiab mob plab.Xyoo 1994, Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb / Lub Koom Haum Ntiaj Teb Kev Tshawb Fawb Txog Kev Tshawb Fawb (WHO / IARC) tau xaiv Helicobacter pylori raws li chav kawm I carcinogen.

Gastric mucosa - lub cev armor ntawm lub plab

Nyob rau hauv ib txwm muaj xwm txheej, lub plab phab ntsa muaj cov txheej txheem ntawm kev tiv thaiv tus kheej zoo tshaj plaws (kev tso tawm ntawm gastric acid thiab protease, kev tiv thaiv ntawm insoluble thiab soluble mucus khaubncaws sab nraud povtseg, tsis tu ncua kev ua si, thiab lwm yam), uas muaj peev xwm tiv thaiv kev cuam tshuam ntawm ntau txhiab tus kab mob. uas nkag los ntawm qhov ncauj.

HP muaj kev ywj pheej flagella thiab cov qauv helical tshwj xeeb, uas tsis yog tsuas yog ua lub luag haujlwm thauj khoom thaum lub sijhawm cov kab mob colonization, tab sis kuj tuaj yeem dhau los ua tus kheej kheej thiab tsim kev tiv thaiv tus kheej morphology hauv qhov chaw hnyav.Nyob rau tib lub sijhawm, Helicobacter pylori tuaj yeem tsim ntau yam co toxins, uas txiav txim siab tias Helicobacter pylori tuaj yeem dhau los ntawm cov kua dej hauv plab los ntawm nws tus kheej lub zog thiab tiv thaiv gastric acid thiab lwm yam tsis zoo, dhau los ua cov kab mob tsuas yog muaj sia nyob hauv tib neeg lub plab. .

Pathogenesis ntawm Helicobacter pylori

1. Dynamic

Cov kev tshawb fawb tau pom tias Helicobacter pylori muaj lub peev xwm txav mus rau hauv ib puag ncig viscous, thiab flagella yog qhov tsim nyog rau cov kab mob ua luam dej mus rau kev tiv thaiv cov hnoos qeev nyob rau saum npoo ntawm lub plab mucosa.

2. Endotoxin-associated protein A (CagA) thiab vacuolar toxin (VacA)

Cytotoxin-associated gene A (CagA) protein secreted los ntawm HP tuaj yeem ua rau cov lus teb hauv zos.CagA-zoo Helicobacter pylori kab mob tuaj yeem ua rau muaj kev pheej hmoo ntawm atrophic gastritis, plab hnyuv metaplasia thiab mob qog noj ntshav.

Vacuolating cytotoxin A (VacA) yog lwm qhov tseem ceeb tshaj plaws pathogenic yam ntawm Helicobacter pylori, uas tuaj yeem nkag mus rau mitochondria los tswj kev ua haujlwm ntawm organelles.

3. Flagellin

Ob lub flagellin proteins, FlaA thiab FlaB, tsim cov khoom tseem ceeb ntawm flagellar filaments.Kev hloov pauv hauv flagellin glycosylation cuam tshuam rau kev txav mus los.Thaum cov qib ntawm FlaA protein glycosylation tau nce, ob qho tib si lub peev xwm tsiv teb tsaws thiab cov colonization load ntawm cov kab mob tau nce.

4. Urea

Urease generates NH3 thiab CO2 los ntawm hydrolyzing urea, uas neutralizes gastric acid thiab nce pH ntawm cov hlwb nyob ib puag ncig.Tsis tas li ntawd, urease koom nrog cov lus teb inflammatory thiab txhawb kev ua kom adhesion los ntawm kev cuam tshuam nrog CD74 receptors ntawm lub plab epithelial hlwb.

5. Heat shock protein HSP60/GroEL

Helicobacter pylori absorbs ib tug series ntawm conserved kub shock proteins, uas co-expression ntawm Hsp60 nrog urease nyob rau hauv E. coli zoo heev tsub kom urease kev ua, cia cov kab mob hloov thiab ciaj sia nyob rau hauv lub hostile ecological niche ntawm tib neeg lub plab.

6. Hook-related protein 2 homolog FliD

FliD yog cov txheej txheem protein uas tiv thaiv qhov ntxeev ntawm flagella thiab tuaj yeem rov qab ntxig flagellin kom loj hlob flagellar filaments.FliD kuj tseem siv los ua ib qho adhesion molecule, paub txog glycosaminoglycan molecules ntawm cov cell cell.Hauv cov chaw muaj kab mob, cov tshuaj tiv thaiv kab mob yog cov cim ntawm kev kis kab mob thiab tuaj yeem siv rau kev kuaj mob serological.

Test Method:

1. Kev kuaj quav quav: Kev kuaj quav quav yog ib qho kev kuaj tsis muaj kab mob rau H. pylori.Kev ua haujlwm muaj kev nyab xeeb, yooj yim thiab ceev, thiab tsis tas yuav tsum muaj kev tswj hwm qhov ncauj ntawm cov tshuaj reagents.

2. Serum antibody detection: Thaum tus kab mob Helicobacter pylori tshwm sim hauv lub cev, tib neeg lub cev yuav muaj cov tshuaj tiv thaiv kab mob Helicobacter pylori hauv cov ntshav vim muaj kev tiv thaiv kab mob.Los ntawm kev nqus ntshav los xyuas qhov concentration ntawm Helicobacter pylori cov tshuaj tiv thaiv, nws tuaj yeem cuam tshuam seb puas muaj Helicobacter pylori hauv lub cev.kab mob kab mob.

3. Kev kuaj ua pa: Qhov no yog ib txoj kev tshuaj xyuas ntau dua tam sim no.Qhov ncauj urea muaj 13C lossis 14C, thiab ua pa ntsuas cov pa roj carbon dioxide uas muaj 13C lossis 14C tom qab lub sijhawm, vim tias yog Helicobacter pylori, urea yuav raug kuaj pom los ntawm nws cov urea tshwj xeeb.Cov enzymes tawg mus rau hauv ammonia thiab carbon dioxide, uas yog exhaled los ntawm lub ntsws los ntawm cov ntshav.

4. Endoscopy: tso cai ua tib zoo saib xyuas ntawm lub plab mucosal nta xws li liab, o, nodular hloov, thiab lwm yam.;endoscopy tsis haum rau cov neeg mob uas muaj teeb meem loj los yog contraindications thiab cov nqi ntxiv ( tshuaj loog, forceps ).

Bioantibody hais txog cov khoom ntawm H.pyloricov lus pom zoo:

H. Pylori Antigen Rapid Test Kit (tom qab Chromatography)

H. Pylori Antibody Rapid Test Kit (Lateral Chromatography)